Author's response to reviews Title:Prognostic implication of intratumoral metabolic heterogeneity in invasive ductal carcinoma of the breast Authors:

Medullary Breast Carcinoma and Invasive Ductal Carcinoma: A Review Study

Background: Medullary breast carcinoma (MBC) is a unique histological subtype of breast cancer. The present study aimed to evaluate the classic and non-classic characteristics of MBC and its differences with IDC. The present review study incorporates 22 years of practical experience from a breast disease research center-based series of cases.Methods: Retrospectively, the medical records of 3,24...

Author's response to reviews Title: Is there a role for the quantification of RRM1 and ERCC1 expression in Pancreatic Ductal Adenocarcinoma? Authors:

Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast

The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...

Study of the Expression of miR-4270 in Plasma of Patients with Breast Invasive Ductal Carcinoma

Detection of tumor-specific microRNAs (miRs) in the blood of cancer patients may provide a unique and valuable biomarker for diagnosis and prognosis. The aim of this study was to investigate whether plasma levels of microRNA-4270 could serve as a potential marker for breast invasive ductal carcinoma. A total of 40 breast cancer patients and 28 controls were recruited in this study. Total RNA wa...

Flowcytometric Analysis of Tumor Associated Macrophages in Invasive Ductal Carcinoma of Breast

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. It is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   Objective: To analyze the status of tumor as...